Enantioselective biotransformation of propranolol to the active metabolite 4-hydroxypropranolol by endophytic fungi
The enantioselective biotransformation of propranolol (Prop) by the endophytic fungi Phomopsis sp., Glomerella cingulata, Penicillium crustosum, Chaetomium globosum and Aspergillus fumigatus was investigated by studying the kinetics of the aromatic hydroxylation reaction silicone-lube with the formation of 4-hydroxypropranolol (4-OH-Prop).Both Prop