ENANTIOSELECTIVE BIOTRANSFORMATION OF PROPRANOLOL TO THE ACTIVE METABOLITE 4-HYDROXYPROPRANOLOL BY ENDOPHYTIC FUNGI

Enantioselective biotransformation of propranolol to the active metabolite 4-hydroxypropranolol by endophytic fungi

The enantioselective biotransformation of propranolol (Prop) by the endophytic fungi Phomopsis sp., Glomerella cingulata, Penicillium crustosum, Chaetomium globosum and Aspergillus fumigatus was investigated by studying the kinetics of the aromatic hydroxylation reaction silicone-lube with the formation of 4-hydroxypropranolol (4-OH-Prop).Both Prop

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Perspective on the Therapeutics of Anti-Snake Venom

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world.Improvement in the therapeutic approaches to envenomation is required to palliate the morbidity and mortality effects of this NTD.The specific therapeut

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Role of pH in Regulating Cancer Pyrimidine Synthesis

Replication is a fundamental aspect of cancer, and replication is about reproducing all the elements and structures that form a cell.Among them are DNA, RNA, enzymes, and coenzymes.All the DNA is doubled during each S (synthesis) cell cycle phase.This means that six billion nucleic acids must be synthesized in each cycle.Tumor growth, proliferation

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